Identified particle measurements at large transverse momenta from p+p to Au+Au collisions at RHIC

Measurements of various particle species over an extended momentum range provide a sensitive experimental tool for investigating particle production mechanisms in hadronic collisions. Comparison of the spectral shapes from different collision centralities measured with the STAR detector at RHIC allows one to study the interplay of soft and hard particle production for mesons and investigate various baryon-meson effects. Systematic studies of identified particle spectra for various colliding systems and different incident energies provide additional insights toward the interplay between fragmentation and non-fragmentation contributions to the particle production. In these proceedings we present a systematic study of transverse momentum spectra for charged pions, protons and antiprotons from Au+Au and Cu+Cu data at sqrt(s_NN)=200 and 62.4 GeV as a function of collision centrality. We compare those measurements with p+p and d+Au data, investigating the system effects on energy loss.Comment: 6 pages, 4 figures, proceedings for the Lake Louise Winter Institute 2007, 19th-24th February 2007, Alberta, Canad

System size dependence of freeze-out properties at RHIC

The STAR experiment at RHIC has measured identified pi(+/-), K(+/-) and p(pbar) spectra and ratios from sqrt(s_NN) = 62.4 and 200 GeV Cu+Cu collisions. The new Cu+Cu results are studied with hydro-motivated blast-wave and statistical model frameworks in order to characterize the freeze-out properties of this system. Along with measurements from Au+Au and p+p collisions, the obtained freeze-out parameters are discussed as a function of collision energy, system size, centrality and inferred energy density. This multi-dimensional systematic study reveals the importance of the collision geometry and furthers our understanding of the QCD phases.Comment: 6 pages, 6 figures, poster proceedings for the Quark Matter 2006 Conference, Shanghai, China, 14th-20th Novermber 2006, submitted to the International Journal of Modern Physics

Summary of Workshop to Review an OMB Report on Regulatory Risk Assessment and Management

Summary of the results of an invitational workshop conducted to peer review the 1990 OMB report, CURRENT REGULATORY ISSUES IN Risk ASSESSMENT AND Risk MANAGENMENTIN REGULATORY PROGRAM OF THE UNITED STATES GOVERNMENT, APRIL 1, 1990 - MARCH 31, 1991

Insights into activity-dependent map formation from the retinotectal system: a middle-of-the-brain perspective

ABSTRACT: The development of orderly topographic maps in the central nervous system (CNS) results from a collaboration of chemoaffinity cues that establish the coarse organization of the projection and activity-dependent mechanisms that fine-tune the map. Using the retinotectal projection as a model system, we describe evidence that biochemical tags and patterned neural activity work in parallel to produce topographically ordered axonal projections. Finally, we review recent experiments in other CNS projections that support the proposition that cooperation between molecular guidance cues and activity-dependent processes constitutes a general paradigm for CNS map formation

Hyper-Rayleigh scattering in centrosymmetric systems

Hyper-Rayleigh scattering (HRS) is an incoherent mechanism for optical second harmonic generation. The frequency-doubled light that emerges from this mechanism is not emitted in a laser-like manner, in the forward direction; it is scattered in all directions. The underlying theory for this effect involves terms that are quadratic in the incident field and involves an even-order optical susceptibility (for a molecule, its associated hyperpolarizability). In consequence, HRS is often regarded as formally forbidden in centrosymmetric media. However, for the fundamental three-photon interaction, theory based on the standard electric dipole approximation, representable as E13, does not account for all experimental observations. The relevant results emerge upon extending the theory to include E12M1 and E12E2 contributions, incorporating one magnetic dipolar or electric quadrupolar interaction, respectively, to a consistent level of multipolar expansion. Both additional interactions require the deployment of higher orders in the multipole expansion, with the E12E2 interaction analogous in rank and parity to a four-wave susceptibility. To elicit the correct form of response from fluid or disordered media invites a tensor representation which does not oversimplify the molecular components, yet which can produce results to facilitate the interpretation of experimental observations. The detailed derivation in this work leads to results which are summarized for the following: perpendicular detection of polarization components both parallel and perpendicular to the pump radiation, leading to distinct polarization ratio results, as well as a reversal ratio for forward scattered circular polarizations. The results provide a route to handling data with direct physical interpretation, to enable the more sophisticated design of molecules with sought nonlinear optical properties

Lentiviral vectors with amplified beta cell-specific gene expression.

An important goal of gene therapy is to be able to deliver genes, so that they express in a pattern that recapitulates the expression of an endogenous cellular gene. Although tissue-specific promoters confer selectivity, in a vector-based system, their activity may be too weak to mediate detectable levels in gene-expression studies. We have used a two-step transcriptional amplification system to amplify gene expression from lentiviral vectors using the human insulin promoter. In this system, the human insulin promoter drives expression of a potent synthetic transcription activator (the yeast GAL4 DNA-binding domain fused to the activation domain of the Herpes simplex virus-1 VP16 activator), which in turn activates a GAL4-responsive promoter, driving the enhanced green fluorescent protein reporter gene. Vectors carrying the human insulin promoter did not express in non-beta-cell lines, but expressed in murine insulinoma cell lines, indicating that the human insulin promoter was capable of conferring cell specificity of expression. The insulin-amplifiable vector was able to amplify gene expression five to nine times over a standard insulin-promoter vector. In primary human islets, gene expression from the insulin-promoted vectors was coincident with insulin staining. These vectors will be useful in gene-expression studies that require a detectable signal and tissue specificity

Dietary sulfur concentration has no effect on In Vitro fermentative activity of ruminal mixed microorganisms

Beef Cattle Research, 2011 is known as Cattlemen’s Day, 2011We previously reported that elevated concentrations of dietary sulfur (0.65% sulfur, dry basis) in finishing diets containing dried distillers grains with solubles decreased dry matter intake and average daily gains of feedlot cattle. Furthermore, high dietary sulfur concentrations yielded lower ruminal concentrations of volatile fatty acids, but were associated with increased ruminal ammonia concentrations and improved total tract digestibility of the diet. The objective of this study was to investigate, in culture tubes, effects of added sulfur on in vitro dry matter disappearance, volatile fatty acid profiles, and ammonia concentrations from substrates containing different sulfur concentrations when fermented by mixed ruminal microorganisms from a steer fed a diet based on corn and alfalfa

Adaptation to a bacterial pathogen in Drosophila melanogaster is not aided by sexual selection.

Theory predicts that sexual selection should aid adaptation to novel environments, but empirical support for this idea is limited. Pathogens are a major driver of host evolution and, unlike abiotic selection pressures, undergo epidemiological and co-evolutionary cycles with the host involving adaptation and counteradaptation. Because of this, populations harbor ample genetic variation underlying immunity and the opportunity for sexual selection based on condition-dependent "good genes" is expected to be large. In this study, we evolved populations of Drosophila melanogaster in a 2-way factorial design manipulating sexual selection and pathogen presence, using a gram-negative insect pathogen Pseudomonas entomophila, for 14 generations. We then examined how the presence of sexual selection and the pathogen, as well as any potential interaction, affected the evolution of pathogen resistance. We found increased resistance to P. entomophila in populations that evolved under pathogen pressure, driven primarily by increased female survival after infection despite selection for resistance acting only on males over the course of experimental evolution. This result suggests that the genetic basis of resistance is in part shared between the sexes. We did not find any evidence of sexual selection aiding adaptation to pathogen, however, a finding contrary to the predictions of "good genes" theory. Our results therefore provide no support for a role for sexual selection in the evolution of immunity in this experimental system